Garlic Oil Enhances Hepatic and Blood Antioxidants During Hamster Buccal Pouch Carcinogenesis
نویسندگان
چکیده
We analyzed the protective effect of garlic oil on hepatic and blood lipid peroxidation and the antioxidant status during buccal pouch carcinogenesis induced by 7,12dimethylbenz[a]anthracene (DMBA) in male Syrian hamsters. Enhanced lipid peroxidation in the liver and blood of tumor-bearing animals was accompanied by a significant decrease in antioxidant levels. Topical application of garlic oil effectively suppressed oral carcinomas, decreased lipid peroxidation, and enhanced antioxidant levels. Our results suggest that garlic oil may exert its chemopreventive effects by modulating lipid peroxidation and enhancing antioxidant status in the liver and blood.
منابع مشابه
Protective effect of sinapic acid against 7,12 dimethyl benz(a)anthracene induced hamster buccal pouch carcinogenesis
The aim of the present study was to evaluate the free radical scavenging and antioxidants in DMBA induced hamster buccal pouch carcinogenesis in golden Syrian hamsters. A total of 32 animals were divided into 4 groups of 8 animals each. Group I served as control and received normal saline only. Group II animals were painted with 0.5% DMBA with liquid paraffin three times a week for 16 weeks on ...
متن کاملChemopreventive and antioxidant efficacy of (6)-paradol in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis.
The present study evaluated the chemopreventive potential of (6)-paradol, a pungent phenolic constituent of ginger, on 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. The mechanistic pathway for the chemopreventive potential of (6)-paradol was evaluated by measuring the status of tumor incidence, volume and burden as well as by analyzing the status of phase II...
متن کاملDiurnal variation of gamma-glutamyl transpeptidase activity during DMBA-induced hamster buccal pouch carcinogenesis.
OBJECTIVE The aim of the present study is to assess the diurnal variation of gamma-glutamyl transpeptidase (GGT) during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. MATERIALS AND METHODS The right buccal pouches of 108 Syrian golden hamsters, divided into three experimental groups, were treated three times weekly with 0.5% DMBA in mineral oil over an 11-w...
متن کاملChemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.
INTRODUCTION Oral carcinoma accounts for 40-50 percent of all cancers in India. Tobacco chewing, smoking and alcohol consumption are the major risk factors associated with the high incidence of oral cancer in India. Our aim was to investigate the chemopreventive potential of curcumin and piperine during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. METHODS...
متن کاملTerminalia Arjuna (Roxb.) Modulates Circulatory Antioxidants on 7,12-dimethylbenz(a)anthracene- induced Hamster Buccal Pouch Carcinogenesis.
OBJECTIVES Oral cancer is the fifth most frequent cancer worldwide and India has recorded the highest incidence (40-50%) of oral malignancy. This study is designed to investigate the effect of aqueous extract of Terminalia arjuna bark (TaBet) on circulatory lipid peroxidation and antioxidant status during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. METHO...
متن کامل